Brain Synapse Machinery Is Finely Tuned

first_imgThe New York Times published a brief article on brain facts that is astonishing, when you think about all that goes on in thinking.  Nicholas Wade reported on a new inventory of the proteins involved in the synapses, the key junctions between neurons.  The research team, led by Seth Grant of the Sanger Institute near Cambridge, England, compiled the first exact inventory of all the protein components of the synaptic information-processing machinery.  No fewer than 1,461 proteins are involved in this biological machinery, they report in the current issue of Nature Neuroscience….    Each neuron in the human brain makes an average 1,000 or so connections with other neurons.  There are 100 billion neurons, so the brain probably contains 100 trillion synapses, its most critical working part.    At the side of a synapse that belongs to the transmitting neuron, an electrical signal arrives and releases packets of chemicals.  The chemicals diffuse quickly across the minute gap between the neurons and dock with receptors on the surface of the receiving neuron.    These receptors feed the signals they receive to a delicate complex of protein-based machines that process and store the information.    The 1,461 genes that specify these synaptic proteins constitute more than 7 percent of the human genome’s 20,000 protein-coding genes, an indication of the synapse’s complexity and importance.    Dr. Grant believes that the proteins are probably linked together to form several biological machines that process the information and change the physical properties of the neuron as a way of laying down a memory.Lest one think there is a lot of leeway in the system for evolution, the article went on to describe what mutations do.  Single mutations in 169 genes, the Sanger team found, cause 269 different human diseases.  “The tolerances of these machines seem to be very fine because almost any mutation in the underlying genes leads to a misshapen protein and, consequently, to disease,” the article said.  Science Daily reported that a single gene deletion leads to the most common form of adult brain cancer.    See also the 11/19/2010 entry on brain-boggling facts.Are you thinking that Darwin doesn’t have a prayer explaining this?  Look: machines made of other machines, information processing, fantastic complexity, very fine tolerance.  If you are thinking rightly, you will be thanking the Maker of your designed brain.    This is the 700th “Amazing Facts” entry in Creation-Evolution Headlines brought to you in over 10 years of reporting.  Putting all of them together would make a sizeable book.  If you appreciate this amazing information made available here for free, consider supporting our site with a year-end donation.  Click the Donate button on the right-hand column.(Visited 14 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Step inside my geocache. — Tschröuwe-Galari (GC3V52D) — Geocache of the Week

first_imgQuite possibly the first time these people ever went inside a geocache. Photo by geocacher xentiscarbonGeocache Name:Tschröuwe-Galari (GC3V52D) Photos:The geocache. No not behind the house, it IS the house. Photo by geocacher MCDeniflInside the geocache. Photo by geocacher DL3BZZSigning the logbook while still inside the geocache. Photo by geocacher moses_was_hereWhat’s the largest geocache you’ve ever found? Tell us and post photos in the comments. Why this is the Geocache of the Week:Giant ammo cans, buckets, even whole cars—there are plenty of large-sized geocaches out there. However, few are large enough for you and a few of your friends to comfortably fit inside. In fact, you could even stretch out and take a mid-day geocaching nap inside this geocache. This geocache was once an unused farm house in the Austrian countryside. The geocache owner decided to breathe new life into this once ‘useless’ structure and turn it into something that brings to joy to geocachers across the world. The real question is, once you’re inside the geocache, do you become a piece of SWAG? What geocachers are saying:“…I’m at the cache and I see a very nice place! Hard to miss. I’m taking a little break here and I’m surprised about this location, never been ‘in’ a geocache…  A favoritie point is well deserved for this beautiful location! ” – Coyote0510“While completing the series of PT Hochalpele, we took a deviation to find this cache without having seeing the pictures. When we arrived we were atonished! This is the biggest cache we have ever found! Fantastic!” – Zascandiles[translated from German] “Super cool idea, we were excited! That was the largest I’ve done so far. We dried off, ate, drank and logged! The break was perfect for us to wait for better weather. I left a favorite here!” – Red-Habanero Difficulty/Terrain Rating:1/3 Continue to explore some of the most engaging geocaches around the globe. Check out all the Geocaches of the Week on the Geocaching blog.If you would like to nominate a Geocache of the Week, just fill out this form. Thanks!Share with your Friends:More SharePrint RelatedGetting warmer… — Fire and Ice (GC4TXB2) — Geocache of the WeekJanuary 8, 2015In “Geocache of the Week”A Cacophony of Creepy Caches – MEGA HERTZ (GC5ENHH) – Geocache of the WeekOctober 30, 2014In “Geocache of the Week”Rubik’s Cache (GC5YGFM) – Geocache of the WeekJuly 30, 2015In “Geocache of the Week”last_img read more

Antetokounmpo unleashed as Bucks take commanding 3-1 lead over Celtics

first_imgPH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Milwaukee Bucks’ Giannis Antetokounmpo (34) reacts after making a basket and drawing a foul as Boston Celtics’ Marcus Morris (13) turns away during the second half of Game 4 of a second-round NBA basketball playoff series in Boston, Monday, May 6, 2019. (AP Photo/Michael Dwyer)BOSTON — When Giannis Antetokounmpo picked up his fourth foul early in the third quarter of a tie game, the Boston Celtics sensed a chance to pull away.Instead, Milwaukee took control.ADVERTISEMENT Panelo: Duterte ‘angry’ with SEA Games hosting hassles MOST READ “It’s always hard to take out Giannis; let’s start there. But at the end of the day, we are conscious of trying to keep him fresh,” Budenholzer said. “It’s hard to find the words (for) what he does for our team, both ends of the court. He’s special, but he’s very hungry. He wants more, and he’s playing that way.”The Bucks have won three straight since losing the opener of the best-of-seven series at home and can eliminate the Celtics in Game 5 at home on Wednesday night. They have not reached the East finals since the ’01 team of Ray Allen and Glenn Robinson fell to Philadelphia’s Allen Iverson and Dikembe Mutombo in seven games.“Good players, when they have an opportunity like this, they don’t waste it,” Antetokounmpo said. “At the end of the day, I’ve got to do whatever it takes to help my team win.”SUMMER TIMEIn what might be his last home game for the Celtics, Kyrie Irving scored 23 points with 10 assists. But he was 7 for 22 from the floor, including 1 for 7 from 3-point range.ADVERTISEMENT Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue Private companies step in to help SEA Games hosting View comments LATEST STORIES Of the game, and the series.Antetokounmpo watched the Bucks bench open a double-digit lead, then returned with a dominating fourth quarter to finish with 39 points and 16 rebounds as Milwaukee beat Boston 113-101 on Monday night to move one win from its first trip to the Eastern Conference finals since 2001.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logistics“If we’re honest with you, when Giannis and Khris (Middleton) go to the bench, you’re concerned,” Bucks coach Mike Budenholzer said after his reserves outscored Boston’s 32-7 in the game and turned a 59-all tie into a 78-68 lead. “But you have confidence that that group can play.”George Hill scored 15 points — nine in the third quarter — and Pat Connaughton had nine points and 10 rebounds off the bench for Milwaukee, which outscored Boston’s bench 42-16 in Game 3. After sitting out the last 8:18 of the third quarter, Antetokounmpo scored 17 points with seven rebounds in the fourth to help the Bucks pull away. Cayetano: Senate, Drilon to be blamed for SEA Games mess Philippine Arena Interchange inaugurated DA eyes importing ‘galunggong’ anew SEA Games hosting troubles anger Duterte Hontiveros presses for security audit of national power grid Beer fear: Japan urged to stock up for Rugby World Cup “Yeah that was killer,” Celtics coach Brad Stevens said. “Their bench comes in, they’ve had no dropoff. Connaughton’s been excellent. George Hill’s been absolutely tremendous.”TIP-INSMilwaukee has won four straight road playoff games. … Marcus Smart, who has been out since tearing a muscle in his side during the second-to-last game of the regular season, played 15 minutes and scored three points, making 1 of 7 attempts from 3-point range. … It was Antetokounmpo’s eighth career 30-point playoff game, tying Marques Johnson for second in franchise history.UP NEXTGame 5 is Wednesday in Milwaukee.Sports Related Videospowered by AdSparcRead Next “Who cares? I’m a basketball player,” said the six-time All-Star, who can become a free agent this summer. “I’m trying to do it all. For me, the 22 shots — I should have shot 30.”After leading all scorers with 26 points in Boston’s Game 1 blowout, Irving has made 19 of 62 shots and just 4 of 20 from 3-point range. He left the court with a few seconds remaining on the clock; many in the crowd had already headed for the exits, but a lone fan shouted at Irving, “Don’t leave!”“I know probably to the outside world we probably don’t stand much of a chance,” Celtics Center Al Horford, who scored 20. “We’re at a low point as a group, I guess that’s the reality. We’ll have to bring that fight to them on Wednesday.”DIFFERENT YEARSBoston beat Milwaukee in seven games in the first round last year and went on to lose to LeBron James and the Cavaliers in seven games in last year’s conference finals. They will have to win three straight — two of them on the road — to return.“I know probably to the outside world we probably don’t stand much of a chance,” said Celtics Center Al Horford, who scored 20. “We’re at a low point as a group, I guess that’s the reality. We’ll have to bring that fight to them on Wednesday.”Marcus Morris Sr. scored 18 with 14 rebounds, and Jayson Tatum had 17 points and 10 boards for Boston.EARLY RUNSBoston led by as many as 11 points before Connaughton made a long 3 at the first-quarter buzzer to make it 30-22. With about five minutes left in the second, the Bucks scored eight straight points to tie it.Boston led 67-65 before Milwaukee scored 13 of the next 14 points — seven of them by Hill, and all of them with Antetokounmpo on the bench — to open a double-digit lead. Don’t miss out on the latest news and information. last_img read more