Researchers map 209 flu virus genomes

first_imgOct 6, 2005 (CIDRAP News) – Influenza researchers marked a milestone yesterday by publishing a report on the complete genetic mapping of 209 samples of human flu viruses, vastly increasing the supply of genetic data on flu. The report, published in Nature, is one of the first fruits of the Influenza Genome Sequencing Project, which aims to trace the genetic blueprints of thousands of flu viruses. The project, announced in November 2004, is a joint effort of the National Institute of Allergy and Infectious Diseases (NIAID), the National Center for Biotechnology Information, the Wadsworth Center of the New York State Department of Health in Albany, and The Institute for Genomic Research (TIGR) in Rockville, Md. The flu genome sequencing project is now being expanded to include avian flu, in an effort to learn how often avian strains cross into humans, the article says. The H5N1 avian strain now circulating in Asia has already infected more than 115 humans. Experts fear it could soon gain the ability to spread readily from person to person, thereby launching a pandemic. “These new data give us the most comprehensive picture to date of how influenza viruses evolve and are transmitted throughout human populations,” NIAID Director Anthony Fauci, MD, said in a news release. He said the new information could lead to better vaccines, drugs, and diagnostic tools for flu. “As a result of this project, the number of complete human H3N2 influenza virus genomes in GenBank [a public online database] has already grown from just seven genomes to over 200,” the article says. The samples analyzed include 207 H3N2 viruses and two H1N2 isolates, which were gathered in New York state over five flu seasons, from 1998-99 through 2003-04. “The sequenced strains were not preselected because of their virulence or unusual characteristics, giving researchers an unbiased view of flu virus evolution as it moved through a varied human population,” the NIAID statement said. See also: They detected a number of mutations (changes in particular amino acids) that occurred during the study period, and also found three cases in which strains traded whole gene segments (reassortments). In July some members of the team reported in detail on the most significant of these events, in which two groups, or clades, of H3N2 viruses acquired the hemagglutinin gene from a third H3N2 group. That gave rise to the Fujian strain of flu, which predominated in the 2003-04 flu season. The vaccine that year was not well matched to the Fujian strain and had reduced effectiveness. The viruses were surprisingly varied. “Even within a geographically constrained set of isolates, we have found surprising genetic diversity, indicating that the reservoir of influenza A strains in the human population—and the concomitant potential for segment exchange between strains—may be greater than was previously suspected,” the researchers write. By carefully cataloging mutations and reassortments, “we can begin to get the first real picture of the rate of mutational events underlying influenza A virus evolution,” the researchers write. The research was done by a large team, with Elodie Ghedin of TIGR listed as the first author. They published their report the same day other teams reported on the re-creation of the deadly 1918 pandemic flu virus and a finding that the 1918 virus closely resembled avian flu viruses. Ghedin E, Sengamalay NA, Shumway M, et al. Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature 2005 Oct 5 (advance online publication) [Full text] Ghedin and colleagues say that until now, scientists had fully mapped and published the genomes of only a few strains of human flu viruses. Most of the published data pertain to short fragments of the genes for the virus’s two key surface proteins, hemagglutinin and neuraminidase. Jul 26, 2005, CIDRAP News story “Flu viruses can evolve in unsuspected ways, study says”last_img read more

New display apartment offers sneak peek inside a luxury Gold Coast development

first_imgThere will be two to five apartments per floor overlooking the skyline, Greg Norman championship golf course or the Hinterland.Most apartments feature two car parks and some will have golf buggy parking.Remaining apartments are selling from $463,000. Residents will also have access to a pool, gym, sauna and barbecue area. The display apartment is open next to the Glades Clubhouse at 1 Glades Drive. Rawcorp’s new apartment project Bellevue at The Glades in Robina.“The buyer feedback has been exceptionally positive on the artist impressions and the purpose-built kitchen and bathroom in our current sales centre across the road. More from news02:37International architect Desmond Brooks selling luxury beach villa11 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago“More than 70 per cent of the development has sold, but for every purchaser that committed to buying without seeing a completed apartment, there were around eight that couldn’t envisage buying … off the plan without seeing the end product.”The display has been furnished by interior designer Nicky Uren from Design Nu, who said buyers also have the chance to buy a furniture package for their new apartment.The development, which has been designed by AG Architects, will include 58 apartments across two buildings, which will be connected at the podium level. MORE NEWS: Prominent property developer plans to offload mansion Renders of Rawcorp’s new apartment project Bellevue at The Glades.CONSTRUCTION on a luxury residential development in Robina has been fast tracked in a bid to offer prospective buyers a sneak peek at what their new apartments will look like.Rawcorp opened its new Bellevue at The Glades display apartment last weekend following public feedback.Marketing Projects SEQ director Kyia Anderson said most of the inquiries had come from downsizers who wanted to see, feel and touch the apartments before committing to buying the luxury abodes.“Downsizing from the family home can be a daunting experience and buyers like to be able to see the size, layout, quality and finishes first hand,” she said. Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 1:46Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -1:46 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD432p432p216p216p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenChoosing an apartment to invest in01:47 MORE NEWS: Price tag attached to Prince’s palacelast_img read more