media captionThe story of the night so far… His campaign is also hopeful they still can take Arizona. What were the other key results? – Advertisement – In the early hours of Wednesday, Mr Trump announced from the White House that he had won and said he would take the election to the Supreme Court. The BBC projects Mr Biden won Michigan. US media forecast he has won Wisconsin. No result has emerged in Pennsylvania. What legal challenges are afoot? Latest updates: Biden takes MichiganDemocrats hopes of gaining US Senate dwindleUS election results in maps and chartsTables turned as Trump voters start to worry The Democratic challenger said his campaign was feeling “very good” about Pennsylvania. Winning all three of these Rust Belt states would make Mr Biden victorious. The Trump campaign is challenging vote counts in the critical states of Wisconsin, Pennsylvania and Michigan. The Trump campaign said the president would formally request a Wisconsin recount, citing “irregularities in several Wisconsin counties”. What are the campaigns saying? – Advertisement – Republican National Committee Chairwoman Ronna McDaniel said: “The fight’s not over. We’re in it.” Not so fast, said the campaign of Republican President Trump.
– Advertisement – A Food and Drug Administration panel on Friday unexpectedly declined to endorse Biogen‘s experimental Alzheimer’s drug aducanumab in a setback for the pharmaceutical company.In an 8-1 vote, the panel said Biogen’s late-stage study didn’t provide “strong evidence” showing that aducanumab effectively treated Alzheimer’s. Two other panelists said it the data was “uncertain.”The FDA could still approve the drug, which would make it the first drug approved to slow cognitive decline in people living with the disease and the first new treatment for Alzheimer’s in nearly 20 years.- Advertisement – Biogen headquarters on Binney Street on Thursday, March 21, 2019 in Cambridge, Massachusetts.Nicolaus Czarnecki | MediaNews Group | Getty Images Biogen’s intravenous drug targets a “sticky” compound in the brain known as beta-amyloid, which is hypothesized to play a role in the devastating disease. Biogen has previously estimated about 1.5 million people with early Alzheimer’s in the U.S. could be candidates for the drug, according to Reuters.Some Alzheimer’s experts and Wall Street analysts have been skeptical about the drug’s benefits, especially after Biogen reversed its decision to seek regulatory approval in 2019.The company shocked investors in October of that year by announcing it was seeking regulatory approval after all after pulling the plug on the drug in March. Biogen scientists said at the time that a new analysis of a larger data set showed that aducanumab “reduced clinical decline in patients with early Alzheimer’s disease.”There are currently no drugs cleared by the FDA that can slow or reverse the mental decline from Alzheimer’s, which is the sixth leading cause of death in the United States. The U.S. agency has approved Alzheimer’s drugs aimed at helping symptoms, not actually reversing or slowing the disease itself.During the meeting on Friday with the Peripheral and Central Nervous System Drugs Advisory Committee, Dr. Billy Dunn, director of the Office of Neuroscience in the FDA’s Center for Drug Evaluation and Research, said there was an “enormous unmet medical need.” “Currently approved treatments do not target the underlying pathology of Alzheimer’s disease and their beneficial effects are modest,” he said, adding there has not been an approval of a treatment for the disease since 2003.In a letter sent to the FDA ahead of the meeting, the Alzheimer’s Association said the publicly released data so far “justifies approval accompanied by a Phase 4 post-marketing surveillance study.”“The alternative, requiring completion of an additional Phase 3 trial, would deny broad access up to four years while it is completed. A four-year delay is too long to wait for millions of Americans facing a progressive, fatal disease. A four-year delay is too long to wait for millions of American caregivers,” the organization said.The FDA’s final decision on Biogen’s drug is expected by March.This is a developing story. Please check back for updates. Shares of Biogen were halted Friday ahead of the meeting of outside experts.Biogen shares had surged Wednesday after FDA staff gave a positive review of the drug. In a 343-page document, the FDA said results from Biogen’s late-stage trial were “highly persuasive” and the study was “capable of providing the primary contribution to a demonstration of substantial evidence of effectiveness” of aducanumab. “Based on the considerations above, the applicant has provided substantial evidence of effectiveness to support approval,” the FDA added.Alzheimer’s disease is a progressive neurodegenerative disorder that slowly destroys memory and thinking skills. The Alzheimer’s Association estimates more than 5 million Americans are living with the disease.- Advertisement – – Advertisement –
Mr Trump has yet to concede the election to his Democratic rival. US President Donald Trump has made his first official public appearance since the election was called for Joe Biden.He attended a ceremony at Arlington National Cemetery in Virginia for Veterans Day.- Advertisement – – Advertisement –
– Advertisement – A nurse attends a protest, organized by the New York State Nurses Association in front of the National Holdings Corporation on May 8, 2020. The nurses protested because congress granted bailouts to corporations and Wall Street billionaires, but not enough for the communities hit hardest by the coronavirus crisis.Night Owls, a themed open thread, appears at Daily Kos seven days a weekCaroline Chen at ProPublica writes—The Enraging Déjà Vu of a Third Coronavirus Wave. Health care workers don’t need patronizing praise. They need resources, federal support, and for us to stay healthy and out of their hospitals. In many cases, none of that is happening:There’s a joke I’ve seen circulating online, over and over during this pandemic, that goes along the lines of, “Months this year: January, February, March, March, March, March, March…”My lips pull into a smile, but my heart’s not in it. […]As a health reporter covering the pandemic, I’ve experienced too many moments of deja vu. This summer, as the virus swept through the South, news footage of overwhelmed hospitals in Houston turning away ambulances recalled similar scenes from March and April in New York City. Now, we’re in the so-called third wave of the pandemic, with the virus slamming into Midwestern states, and this week, Dr. Gregory Schmidt, associate chief medical officer at the University of Iowa Hospitals and Clinics, said his colleagues are converting 16 hospital beds into new ICU beds in anticipation of an influx of COVID-19 patients. “People in leadership are starting to say things in meetings like, ‘I have a sense of impending doom.’” – Advertisement –
The feature was initially spotted by a Reddit user two months ago and it now appears to be rolling out to more users. Quick Picks reportedly has five pages of four songs each that you can keep swiping over.The new Quick Picks category consists of a carousel featuring four songs on each pagePhoto Credit: Reddit/ _DavidCastle_ – Advertisement – – Advertisement – YouTube Music is rolling out a new Quick Picks section on its homepage, multiple Reddit users have posted. The new Quick Picks category consists of a carousel featuring four songs on each page. On selecting a song, a radio playlist of similar songs will be generated. YouTube Music already has a Start Radio option that plays a number of songs similar to the one you are listening to, but the Quick Picks section seems to be an even more efficient, prominent way of introducing users to more music of their taste.Reddit users posted about spotting the new Quick Picks section on YouTube Music. The suggested songs, according to the post, are sometimes songs they have already heard several times but not liked. Quick Picks is positioned prominently in the Homepage, below Your Favourites and Mixed For You.- Advertisement – A report by 9to5Google confirmed that the feature has begun rolling out to Android and iOS users, as well as YouTube Music on the Web.With Google Play Music shutting down and Google encouraging users to shift to YouTube Music, the latter has introduced several new features to make the music streaming service more efficient. Last week, YouTube Music added an activity bar that lets users customise the homepage by giving them easy access to music for featured activities like workout and focus. It also introduced seven personalised My Mix playlists for users on the Home page, featuring diverse artists and different moods.Which is the best TV under Rs. 25,000? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below.- Advertisement –
May 4, 2005 (CIDRAP News ) – With a federal judge’s permission, the US Department of Defense (DoD) has announced it will resume giving anthrax shots to military personnel, but on a strictly voluntary basis.The DoD’s mandatory anthrax immunization program had been suspended since October 2004, when US District Judge Emmet G. Sullivan ruled that the Food and Drug Administration (FDA) did not follow proper procedures in approving the vaccine for inhalational anthrax.In January the FDA issued an “emergency use authorization” (EUA) permitting DoD to resume the vaccinations, but only on a voluntary basis. On Apr 6, Sullivan granted a DoD request to resume giving the shots under the terms of the emergency authorization.Yesterday the Pentagon announced it was ready to resume giving anthrax shots. Officials said the vaccinations would mostly be limited to military units assigned to the Central Command area, which includes the Middle East, and to troops serving in Korea and in homeland bioterrorism defense.”The implementing program requires commanders to follow EUA conditions very carefully, providing members of the armed services both education on the program and an option to refuse the vaccination without penalty,” the DoD announcement said.Dr. William Winkenwerder, assistant secretary of defense for health affairs, called the immunization program a “vital protection measure for military personnel, who are at increased risk of exposure to an anthrax attack.”A DoD policy memo about the program says the EUA is scheduled to expire on July 27, less than 3 months away. “At that time, other initiatives may result in resumption of the normal AVIP [Anthrax Vaccine Immunization Program], including mandatory vaccinations for selected personnel,” the memo says. “Alternatively, the EUA may be extended or other direction may be provided.”Perry Bishop, a Pentagon spokesman, said DoD will continue to press for mandatory vaccination, according to an Associated Press report published yesterday.The DoD memo says all personnel eligible for anthrax vaccination must be told they may refuse the shots and will not be punished. Troops must be told they will not be discharged for refusing and they can still be deployed. However, personnel must also be told, “Your military and civilian leaders strongly recommend anthrax vaccination,” the memo states.Personnel will be given a brochure that explains the known and potential benefits and risks of vaccination as well as the alternatives to vaccination.Before Sullivan’s ruling, anthrax shots were mandatory for personnel serving in areas where the risk of anthrax attack was considered high. More than 1.3 million troops had been vaccinated in the program, which began in 1998. But hundreds of troops refused the shots because of concern about side effects, and some were disciplined or discharged from the service.Sullivan’s ruling came in a lawsuit filed by six DoD personnel and civilian contractor employees who objected to the shots. In an initial ruling in December 2003, the judge ordered DoD to stop requiring the shots on the ground that the FDA had never specifically approved the vaccine for inhalational anthrax. The vaccine was originally licensed in 1970.The FDA responded immediately by declaring that the vaccine was safe and effective for all forms of anthrax. Sullivan then lifted his injunction in January 2004. But in his subsequent ruling in October 2004, Sullivan said the FDA had failed to follow its own rules in declaring the vaccine safe for all forms of the disease.Last December, military officials asked the Department of Health and Human Services (HHS) for emergency authority to resume the vaccination program. Under the Project Bioshield Act of 2004, the FDA, in a declared emergency, can authorize the use of a medical product that has not gained ordinary FDA approval. The FDA then issued the emergency authorization on Jan 27, but said the shots had to be voluntary.The anthrax vaccine used by DoD requires six shots over a period of 18 months, followed by annual boosters. Last November HHS awarded an $877 million contract for a new anthrax vaccine that officials hope will require fewer doses and have fewer side effects, but that vaccine is intended to go in a stockpile for civilian use.See also:May 3 DoD news releaseDoD policy memo
Oct 6, 2005 (CIDRAP News) Influenza researchers marked a milestone yesterday by publishing a report on the complete genetic mapping of 209 samples of human flu viruses, vastly increasing the supply of genetic data on flu. The report, published in Nature, is one of the first fruits of the Influenza Genome Sequencing Project, which aims to trace the genetic blueprints of thousands of flu viruses. The project, announced in November 2004, is a joint effort of the National Institute of Allergy and Infectious Diseases (NIAID), the National Center for Biotechnology Information, the Wadsworth Center of the New York State Department of Health in Albany, and The Institute for Genomic Research (TIGR) in Rockville, Md. The flu genome sequencing project is now being expanded to include avian flu, in an effort to learn how often avian strains cross into humans, the article says. The H5N1 avian strain now circulating in Asia has already infected more than 115 humans. Experts fear it could soon gain the ability to spread readily from person to person, thereby launching a pandemic. “These new data give us the most comprehensive picture to date of how influenza viruses evolve and are transmitted throughout human populations,” NIAID Director Anthony Fauci, MD, said in a news release. He said the new information could lead to better vaccines, drugs, and diagnostic tools for flu. “As a result of this project, the number of complete human H3N2 influenza virus genomes in GenBank [a public online database] has already grown from just seven genomes to over 200,” the article says. The samples analyzed include 207 H3N2 viruses and two H1N2 isolates, which were gathered in New York state over five flu seasons, from 1998-99 through 2003-04. “The sequenced strains were not preselected because of their virulence or unusual characteristics, giving researchers an unbiased view of flu virus evolution as it moved through a varied human population,” the NIAID statement said. See also: They detected a number of mutations (changes in particular amino acids) that occurred during the study period, and also found three cases in which strains traded whole gene segments (reassortments). In July some members of the team reported in detail on the most significant of these events, in which two groups, or clades, of H3N2 viruses acquired the hemagglutinin gene from a third H3N2 group. That gave rise to the Fujian strain of flu, which predominated in the 2003-04 flu season. The vaccine that year was not well matched to the Fujian strain and had reduced effectiveness. The viruses were surprisingly varied. “Even within a geographically constrained set of isolates, we have found surprising genetic diversity, indicating that the reservoir of influenza A strains in the human populationand the concomitant potential for segment exchange between strainsmay be greater than was previously suspected,” the researchers write. By carefully cataloging mutations and reassortments, “we can begin to get the first real picture of the rate of mutational events underlying influenza A virus evolution,” the researchers write. The research was done by a large team, with Elodie Ghedin of TIGR listed as the first author. They published their report the same day other teams reported on the re-creation of the deadly 1918 pandemic flu virus and a finding that the 1918 virus closely resembled avian flu viruses. Ghedin E, Sengamalay NA, Shumway M, et al. Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature 2005 Oct 5 (advance online publication) [Full text] Ghedin and colleagues say that until now, scientists had fully mapped and published the genomes of only a few strains of human flu viruses. Most of the published data pertain to short fragments of the genes for the virus’s two key surface proteins, hemagglutinin and neuraminidase. Jul 26, 2005, CIDRAP News story “Flu viruses can evolve in unsuspected ways, study says”
Jun 25, 2007 (CIDRAP News) – The World Health Organization (WHO) today confirmed two H5N1 avian influenza cases, one in a 4-year-old Egyptian boy and the other in a 3-year-old Indonesian girl.The boy is from Qena governorate in southern Egypt. He got sick on Jun 20 and was admitted to the hospital the next day, where he is in stable condition, according to a WHO statement.He is Egypt’s 37th H5N1 case-patient; 15 cases have been fatal. Egypt’s last two confirmed H5N1 cases, both in children, also occurred in Qena governorate.Initial investigation indicates that the boy was exposed to dead poultry, the WHO said. The test results were confirmed by Egypt’s health ministry, the country’s Central Public Health Laboratory, and US Naval Medical Research Unit 3 (NAMRU-3), which is a WHO reference laboratory.The Indonesian girl, from Riau province in central Sumatra, fell ill on Jun 18 and has since recovered, the WHO said. The source of her infection appears to be exposure to sick and dead poultry, the WHO said. Indonesia now has had 101 cases with 80 deaths.Azizman Daad, the avian flu team leader at a hospital in the Riau capital of Pekanbaru, said the girl was treated with oseltamivir (Tamiflu) as soon as she was admitted, Agence-France Presse (AFP) reported on Jun 23. She was to remain in the hospital for a week of observation, the report said.The two new cases boost the WHO’s global H5N1 total to 315 cases, with the number of deaths remaining at 191.See also: Jun 25 WHO statement on Egyptian patientJun 25 WHO statement on Indonesian patient
In order to inform visitors, a free tourist guide Međimurje was published, in which the latest and most useful information about this county was collected for the third year in a row. It contains important telephone numbers and other practical information and introduces the reader to the most important attractions of Međimurje’s popular destinations, and in addition to the print edition, it is also available online.Međimurje has become the most popular continental destination in Croatia, and numerous natural beauties, cultural attractions, various events and a revived tradition are the reasons why every visitor gladly returns to Međimurje and records a constant number of visitors every year. “With the various attractions and facilities in Međimurje that we have and offer, if we add to that the hospitality and kindness of the hosts, about which word has spread far and wide, you will get a real tourist experience. This is exactly the ultimate goal and direction in which Međimurje County strives to move and succeeds”They point out from the Tourist Board of Međimurje County and add that by leafing through the guide, tourists can choose the way they want to spend an active vacation, the event they want to visit or decide which institution to visit.The guide was published in cooperation with LifeClass Terme Sveti Martin, the Tourist Board of Međimurje County, the Tourist Boards of Sveti Martin na Muri, Nedelišće, Štrigova and Prelog, and is available in Croatian and German. It can be downloaded for free from internet and in printed form in tourist boards throughout the county and in LifeClass Terme Sveti Martin.
Late last night, according to the Ministry of the Interior, Vatrene was greeted by a total of about 550 people. Incredibly! Undescribable!This is the best advertisement ever for Croatia, which has been written about, published on social networks, researched in the world of the Internet like never before.Two days ago, Croatia was mentioned in the media 30% more than after the semifinals all over the world, according to Mediatoolkit data. The numbers are huge and have never been recorded in the history of Croatia – more than ever before the semifinals, said Tomislav Grubisic from Mediatoolkit, a tool that monitors what is written about anyone on the entire Internet in real time, and added: “According to these statistics, more texts about Croatia will be published on the Internet today than have been published in its entire history since its founding. ” Grubisic pointed out. How it will be today and these days after such a welcome in Zagreb and the whole of Croatia, we can only dream and find it difficult to measure everything.This is just another proof that athletes are our best ambassadors and that we need to focus much more seriously and strategically on how to connect and promote tourism, culture, economy through sports success…And as sport, and especially football as the “most important sideline in the world”, attracts the masses, they thus directly affect the increase in consumption and bring a significant impetus to the economy. Thus, according to the estimates of the Croatian Chamber of Commerce, HRK 9.277.224.291,92 was spent in Croatia during the World Cup in Russia.Consumption related to major sports competitions is growing by about 10 percent, mostly in the categories of audio-visual equipment or television, sports equipment, ie fan props, travel arrangements (charter flights organized to go to matches) and in the category of food and beverages; primarily snacks, beer and other alcoholic beverages. “Consumption in retail trade compared to the same period last year was increased, especially on the day before the matches and on the day of the matches, on average between 11 and 15 percent”, She pointed out Director of the Trade Department of the Croatian Chamber of Commerce Tomislav Ravlić based on fiscalization data for the period from June 15 to July 15, 2018, how long the World Cup lasted.Compared to the same period in 2017, Ravlić points out, last year in this period the turnover in retail trade, according to the data from the fiscalization system, was lower by about 5 percent (4,56%). “In the hospitality industry, for example, on the day of the matches, the turnover grew on average by 10 percent and more. The record was set on the day of the semi-finals in the match against England when the turnover in the hospitality industry grew by 17 percent, while during the finals the increase was 13 percent.”, Ravlić points out. A total of HRK 878.824.104,83 was fiscalized in the hospitality industry, or about 3% more than in the same period last year.Croats ate more than 10 million PIK kebabs during the championshipPIK reported that during the World Cup, PIK Vrbovec sold more than 10 million kebabs, more than 2,2 million packs of cold cuts and over 2 million sausages.Although the numbers themselves sound impressive they gain even more weight when compared to sales results at Christmas time when sausages are traditionally eaten in increased quantities. Namely, during Advent in Zagreb, Croats ate more than 700.000 PIK sausages, and during the championship that number increased almost 3 times more, more than 2 million sausages were sold. When it comes to cold cuts, over 2,2 million packs of cold cuts were sold during the World Cup. Sales of durable cold cuts are growing by 30%, and the first choice of consumers are Winter and Tea. From PIK Vrbovec, they say how it is the company in this period recorded an increase in the volume of products sold by more than 10%.Related news:”CROATIA FULL OF EXCELLENT PLAYERS” CNTB CAMPAIGN ON SOCIAL NETWORKSTHIS SHORT STORY WILL BEST SHOW YOU WHAT CROATIA HAS MADE FOR TOURISM IN RUSSIACROATIA – FULL OF CHAMPIONS, A CAMPAIGN THAT SHOULD START TODAY!